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KMID : 1138520180210040226
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Journal of Pharmacopuncture
2018 Volume.21 No. 4 p.226 ~ p.240
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Neuroprotective Agents in the Intensive Care Unit - Neuroprotective Agents in ICU -
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Panahi Yunes
Mojtahedzadeh Mojtaba
Najafi Atabak
Rajaee Seyyed Mahdi
Torkaman Mohammad
Sahebkar Amirhossein
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Abstract
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Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.
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KEYWORD
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neuroprotection, intensive care unit, stroke
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